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Perry, George

One or more keywords matched the following items that are connected to Perry, George

Item Type	Name
Academic Article	RNA oxidation in Alzheimer disease and related neurodegenerative disorders.
Academic Article	Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation.
Academic Article	Mitochondria: a therapeutic target in neurodegeneration.
Academic Article	Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons.
Academic Article	Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.
Academic Article	DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease.
Academic Article	Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Academic Article	Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.
Academic Article	Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers.
Academic Article	Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Academic Article	Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.
Academic Article	Cellular prion protein is essential for oligomeric amyloid-?-induced neuronal cell death.
Academic Article	Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Academic Article	Do ?-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration?
Academic Article	The impairment of insulin signaling in Alzheimer's disease.
Academic Article	Intrahippocampal amyloid-? (1-40) injections injure medial septal neurons in rats.
Academic Article	LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Academic Article	Mark A. Smith: neurocytochemistry innovator.
Academic Article	The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.
Academic Article	Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
Academic Article	Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Academic Article	Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.
Academic Article	Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass.
Academic Article	From Neurodegeneration to Brain Health: An Integrated Approach.
Academic Article	Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.
Academic Article	Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease.
Academic Article	Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model.
Academic Article	Pathomechanisms of TDP-43 in neurodegeneration.
Academic Article	The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease.
Academic Article	TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease.
Academic Article	Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders.
Academic Article	Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex.
Academic Article	TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration.
Academic Article	TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
Academic Article	Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances.
Academic Article	Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Academic Article	The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
Academic Article	Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.
Academic Article	The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
Academic Article	Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
Academic Article	4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis.
Academic Article	Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Academic Article	Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Academic Article	A metabolic basis for Alzheimer disease.
Academic Article	Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
Academic Article	Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.
Academic Article	Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
Academic Article	Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
Academic Article	Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.
Academic Article	Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
Academic Article	Oxidative stress increases expression and activity of BACE in NT2 neurons.
Academic Article	Is Alzheimer's disease a mitochondrial disorder?
Academic Article	Role of mitochondrial dysfunction in Alzheimer's disease.
Academic Article	Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology.
Academic Article	Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells.
Academic Article	Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
Academic Article	Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
Academic Article	Oxidative damage in the olfactory system in Alzheimer's disease.
Academic Article	Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
Academic Article	Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
Academic Article	Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.
Academic Article	Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Academic Article	Perspectives on the amyloid-beta cascade hypothesis.
Academic Article	Neuroprotective properties of Bcl-w in Alzheimer disease.
Academic Article	Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease.
Academic Article	Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
Academic Article	Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Academic Article	The cell cycle in Alzheimer disease: a unique target for neuropharmacology.
Academic Article	P38 activation mediates amyloid-beta cytotoxicity.
Academic Article	Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells.
Academic Article	Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Academic Article	Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.
Academic Article	Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
Academic Article	Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
Academic Article	c-Jun phosphorylation in Alzheimer disease.
Academic Article	Staying connected: synapses in Alzheimer disease.
Academic Article	Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
Academic Article	Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease.
Academic Article	Oxidative stress and neurodegeneration.
Academic Article	4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
Academic Article	Metal ions and oxidative protein modification in neurological disease.
Academic Article	The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.
Academic Article	Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.
Academic Article	Compensatory responses induced by oxidative stress in Alzheimer disease.
Academic Article	Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Academic Article	Involvement of oxidative stress in Alzheimer disease.
Academic Article	Apoptosis in Alzheimer disease: a mathematical improbability.
Academic Article	Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
Academic Article	Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain.
Academic Article	Indices of metabolic dysfunction and oxidative stress.
Academic Article	Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease.
Academic Article	Oxidative stress and neurotoxicity.
Academic Article	Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease.
Academic Article	Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.
Academic Article	The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse.
Academic Article	The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
Academic Article	Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches.
Academic Article	Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease.
Academic Article	Tau--an inhibitor of deacetylase HDAC6 function.
Academic Article	Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
Academic Article	BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Academic Article	Signal transduction cascades associated with oxidative stress in Alzheimer's disease.
Academic Article	Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Academic Article	The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Concept	Communication
Concept	Motor Neurons
Concept	Multiple Sclerosis
Concept	Neurons
Concept	Neurons, Afferent
Concept	Microglia
Academic Article	Ultrastructural analysis of a murine model of congenital hydrocephalus produced by overexpression of transforming growth factor-beta1 in the central nervous system.
Academic Article	Tryptamine induces axonopathy and mitochondriopathy mimicking neurodegenerative diseases via tryptophanyl-tRNA deficiency.
Academic Article	Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?
Academic Article	An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1.
Academic Article	Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.
Academic Article	Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.
Academic Article	Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.
Academic Article	Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.
Academic Article	Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis.
Academic Article	Influence of neuronal location on antigenic properties of neurofibrillary tangles.
Academic Article	Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease.
Academic Article	Neurochemistry of dementia: establishing the links.
Academic Article	Hirano body filaments contain actin and actin-associated proteins.
Academic Article	Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
Academic Article	Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy.
Academic Article	Hirano bodies contain tau protein.
Academic Article	Dystrophic neurites define diffuse as well as core-containing senile plaques in Alzheimer's disease.
Academic Article	Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease.
Academic Article	The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion.
Academic Article	Evidence for oxidative stress in Pick disease and corticobasal degeneration.
Academic Article	Widespread peroxynitrite-mediated damage in Alzheimer's disease.
Academic Article	Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.
Academic Article	Radical AGEing in Alzheimer's disease.
Academic Article	Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases.
Academic Article	Alzheimer disease: an imbalance of proteolytic regulation?
Academic Article	Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.
Academic Article	Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.
Academic Article	Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
Academic Article	Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease.
Academic Article	4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.
Academic Article	Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
Academic Article	Striation is the characteristic neuritic abnormality in Alzheimer disease.
Academic Article	Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease.
Academic Article	Apoptosis and Alzheimer's disease.
Academic Article	The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction.
Academic Article	CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.
Academic Article	Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
Academic Article	In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
Academic Article	In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Academic Article	Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?
Academic Article	Redox-active iron mediates amyloid-beta toxicity.
Academic Article	Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.
Academic Article	Protein disulfide isomerase in Alzheimer disease.
Academic Article	Biochemistry of neurodegeneration.
Academic Article	Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.
Academic Article	A suicide note from Alzheimer disease neurons?
Academic Article	RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.
Academic Article	Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Academic Article	Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.
Academic Article	Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau.
Academic Article	Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.
Academic Article	Oxidative damage in Alzheimer's disease: the metabolic dimension.
Academic Article	Activation of NADPH oxidase in Alzheimer's disease brains.
Academic Article	Oxidative stress in Alzheimer's disease.
Academic Article	Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
Academic Article	Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome.
Academic Article	Do neurons have a choice in death?
Academic Article	Mitochondrial abnormalities in Alzheimer's disease.
Academic Article	Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease.
Academic Article	Abortive apoptosis in Alzheimer's disease.
Academic Article	Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Academic Article	Oxidative damage is the earliest event in Alzheimer disease.
Academic Article	Possible protective mechanisms of heme oxygenase-1 in the brain.
Academic Article	Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.
Academic Article	Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
Academic Article	Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.
Academic Article	Brain and brawn: parallels in oxidative strength.
Academic Article	Causes of oxidative stress in Alzheimer disease.
Academic Article	Neuronal binucleation in Alzheimer disease hippocampus.
Academic Article	Oxidative RNA damage and neurodegeneration.
Academic Article	Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.
Academic Article	Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
Academic Article	A novel perspective on tau in Alzheimer's disease.
Academic Article	Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders.
Academic Article	Inhibition of Calpain Protects Against Tauopathy in Transgenic P301S Tau Mice.
Grant	RCMI Center for Interdiscplinary Health Research CIHR
Grant	RCMI Center for Interdiscplinary Health Research CIHR
Grant	AMYLOID PRECURSOR IN ALZHEIMER DISEASE
Grant	NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE
Academic Article	Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration.
Academic Article	A Multilevel View of the Development of Alzheimer's Disease.
Academic Article	A brief guide to the science and art of writing manuscripts in biomedicine.
Academic Article	Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.
Academic Article	Mitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline.
Academic Article	Retinal Neurodegeneration in Euglycemic Hyperinsulinemia, Prediabetes, and Diabetes.

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